824 research outputs found

    El delito de infanticidio en la reforma penal

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    Fil: Ure, Ernesto J. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Penal. Buenos Aires, Argentina"Relación leída en las Cuartas Jornadas Médicolegales y Criminológicas efectuadas del 12 al 16 de agosto de 1968, organizadas por la Sociedad de Ciencias Criminales y Medicina Legal de Tucumán

    Abstractions, accounts and grid usability

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    The vision of the Grid is one of seamless, virtual and constantly changing resources where users need not concern themselves about details, such as exactly where an application is running or where their data is being stored. However, seamless and virtual often imply a lack of control that users may be wary of, or even opposed to. Drawing upon our studies of HCI and of collaborative work, this paper examines whether the Grid development community should be taking this vision literally and argues for the need for accountability of systems ‘in interaction’. We give examples of an alternative approach that seeks to provide ways in which administrators, technical support and user communities can make sense of the behaviour of the complex socio-technical ensembles that are the reality of Grids

    Production of ethyl acetate from pyrolysis of lignin model compound guaiacylglycerol-β-guaiacyl using TGA-MS

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    Due to the complex chemical structure of lignin, the fundamental chemistry underlying its pyrolysis behaviour is poorly understood. A detailed knowledge of this chemistry would allow for the construction of detailed predictive chemical kinetic models, which could be used to maximise the efficiency of the pyrolysis process. Lignin is comprised of three monolignols, guaiacyl, p-hydroxyphenyl and syringyl. These are joined together by aryl ether linkages of which β-O-4 is the most common, representing approximately 50% of the linkages found in lignin.[1] In this study, pyrolysis (20oC/minute heating rate) was carried out on a lignin model compound, guaiacylglycerol-β-guaiacyl ether (GGE). GGE is composed of two guaiacyl subunits connected by a β-O-4 linkage, making it broadly representative of the lignin motif and as such an important lignin model compound. A detailed understanding of the thermal degradation of GGE under pyrolysis conditions will provide valuable information of the role of the β-O-4 linkage in lignin. Please click Additional Files below to see the full abstract

    Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity

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    Serine proteases in the adult CNS contribute both to activity-dependent structural changes accompanying learning and to the regulation of excitotoxic cell death. Brain serine protease 1 (BSP1)/neuropsin is a trypsin-like serine protease exclusively expressed, within the CNS, in the hippocampus and associated limbic structures. To explore the role of this enzyme, we have used gene targeting to disrupt this gene in mice. Mutant mice were viable and overtly normal; they displayed normal hippocampal long-term synaptic potentiation (LTP) and exhibited no deficits in spatial navigation (water maze). Nevertheless, electrophysiological studies revealed that the hippocampus of mice lacking this specifically expressed protease possessed an increased susceptibility for hyperexcitability (polyspiking) in response to repetitive afferent stimulation. Furthermore, seizure activity on kainic acid administration was markedly increased in mutant mice and was accompanied by heightened immediate early gene (c-fos) expression throughout the brain. In view of the regional selectivity of BSP1/neuropsin brain expression, the observed phenotype may selectively reflect limbic function, further implicating the hippocampus and amygdala in controlling cortical activation. Within the hippocampus, our data suggest that BSP1/neuropsin, unlike other serine proteases, has little effect on physiological synaptic remodeling and instead plays a role in limiting neuronal hyperexcitability induced by epileptogenic insult

    Multiple-Criteria Decision Analysis and characterisation of phase change materials for waste heat recovery at high temperature for sustainable energy-intensive industry

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    A latent heat storage system based on Phase Change Materials (PCMs) is proposed to increase the energy and environmental efficiency by recovering and storing waste heat from combustion gases or other surplus sources at in the energy-intensive industries (EII), currently unused. The final configuration design is specifically adapted to the plant operational requirements, by means of a methodology combining the search of the best conceptual design and a proper selection of core PCMs. To that end, a selection of suitable PCM is carried out by using characterisation techniques and thermal stability testing. Furthermore, relevant key factors are weighted by an in-house Multiple-Criteria Decision Analysis (MCDA) to define the most promising design options to be implemented in two plants belonging to the EII sector. For the ceramic sector, the design resulted in a shell-and-tube system with 1188 kg of a PCM melting at 885 °C and encapsulated in double concentric tubes, involving a storage capacity of 227 MJ. Similarly, 1606 kg of PCM, whose phase-change temperature is 509 °C, is selected for the steel sector providing a PCM-TES system capable to store 420 MJ
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